产品参数
Preci? rat(大鼠) Zbtb49 (基因ID:305428) qPCR引物对 (全名:zinc finger and BTB domain containing 49;别名:Zfp509,Znf509) Preci? rat(大鼠) Zbtb48 (基因ID:362668) qPCR引物对 (全名:zinc finger and BTB domain containing 48;别名:Hkr3) Preci? rat(大鼠) Zbtb47 (基因ID:316087) qPCR引物对 (全名:zinc finger and BTB domain containing 47;别名:Zfp651,RGD1562434) Preci? rat(大鼠) Zbtb46 (基因ID:311718) qPCR引物对 (全名:zinc finger and BTB domain containing 46;别名:Btbd4) Preci? rat(大鼠) Zbtb45 (基因ID:308366) qPCR引物对 (全名:zinc finger and BTB domain containing 45;别名:Zfp499,Znf499) Preci? rat(大鼠) Zbtb44 (基因ID:363035) qPCR引物对 (全名:zinc finger and BTB domain containing 44;别名:Btbd15,RGD1308984) Preci? rat(大鼠) Zbtb43 (基因ID:311872) qPCR引物对 (全名:zinc finger and BTB domain containing 43;别名:Zfp297b) Preci? rat(大鼠) Zbtb42 (基因ID:691556) qPCR引物对 (全名:zinc finger and BTB domain containing 42;别名:) Preci? rat(大鼠) Zbtb41 (基因ID:289052) qPCR引物对 (全名:zinc finger and BTB domain containing 41;别名:) Preci? rat(大鼠) Zbtb40 (基因ID:362635) qPCR引物对 (全名:zinc finger and BTB domain containing 40;别名:RGD1309866) Preci? rat(大鼠) Zbtb39 (基因ID:299510) qPCR引物对 (全名:zinc finger and BTB domain containing 39;别名:RGD1306532) Preci? rat(大鼠) Zbtb38 (基因ID:315936) qPCR引物对 (全名:zinc finger and BTB domain containing 38;别名:RGD1310136) Preci? rat(大鼠) Zbtb37 (基因ID:304918) qPCR引物对 (全名:zinc finger and BTB domain containing 37;别名:RGD1308731) Preci? rat(大鼠) Zbtb34 (基因ID:689174) qPCR引物对 (全名:zinc finger and BTB domain containing 34;别名:) Preci? rat(大鼠) Zbtb33 (基因ID:501506) qPCR引物对 (全名:zinc finger and BTB domain containing 33;别名:RGD1566309) Preci? rat(大鼠) Zbtb32 (基因ID:688845) qPCR引物对 (全名:zinc finger and BTB domain containing 32;别名:) Preci? rat(大鼠) Zbtb26 (基因ID:311910) qPCR引物对 (全名:zinc finger and BTB domain containing 26;别名:) Preci? rat(大鼠) Zbtb25 (基因ID:314245) qPCR引物对 (全名:zinc finger and BTB domain containing 25;别名:KUP,Zfp50,Znf46) Preci? rat(大鼠) Zbtb24 (基因ID:365590) qPCR引物对 (全名:zinc finger and BTB domain containing 24;别名:Bif1a,ZNF450) Preci? rat(大鼠) Zbtb22 (基因ID:309630) qPCR引物对 (全名:zinc finger and BTB domain containing 22;别名:Bing1,Zfp297,Znf297) Preci? rat(大鼠) Zbtb21 (基因ID:304056) qPCR引物对 (全名:zinc finger and BTB domain containing 21;别名:Zfp295,Znf295) Preci? rat(大鼠) Zbtb20 (基因ID:288105) qPCR引物对 (全名:zinc finger and BTB domain containing 20;别名:RGD1560387) Preci? rat(大鼠) Zbtb18 (基因ID:64619) qPCR引物对 (全名:zinc finger and BTB domain containing 18;别名:Rp58,Zfp238,Znf238) Preci? rat(大鼠) Zbtb17 (基因ID:313666) qPCR引物对 (全名:zinc finger and BTB domain containing 17;别名:Zfp100) Preci? rat(大鼠) Zbtb16 (基因ID:353227) qPCR引物对 (全名:zinc finger and BTB domain containing 16;别名:Lx,Plzf,Zfp145,Znf145) Preci? rat(大鼠) Zbtb14 (基因ID:282825) qPCR引物对 (全名:zinc finger and BTB domain containing 14;别名:Zf5,Zfp161) Preci? rat(大鼠) Zbtb12 (基因ID:309613) qPCR引物对 (全名:zinc finger and BTB domain containing 12;别名:Ng35) Preci? rat(大鼠) Zbtb11 (基因ID:304010) qPCR引物对 (全名:zinc finger and BTB domain containing 11;别名:) Preci? rat(大鼠) Zbtb10 (基因ID:80338) qPCR引物对 (全名:zinc finger and BTB domain containing 10;别名:Rinzf,ania-11) Preci? rat(大鼠) Zbtb9 (基因ID:294289) qPCR引物对 (全名:zinc finger and BTB domain containing 9;别名:3930402F13Rik) Preci? rat(大鼠) Zbtb8b (基因ID:500553) qPCR引物对 (全名:zinc finger and BTB domain containing 8b;别名:Zbtb8,Zbtb8l,RGD1562327) Preci? rat(大鼠) Zbtb8a (基因ID:313049) qPCR引物对 (全名:zinc finger and BTB domain containing 8a;别名:Zbtb8) Preci? rat(大鼠) Zbtb7c (基因ID:679155) qPCR引物对 (全名:zinc finger and BTB domain containing 7C;别名:) Preci? rat(大鼠) Zbtb7b (基因ID:295248) qPCR引物对 (全名:zinc finger and BTB domain containing 7B;别名:Zfp67) Preci? rat(大鼠) Zbtb7a (基因ID:117107) qPCR引物对 (全名:zinc finger and BTB domain containing 7a;别名:Lrf,OCZF,Zbtb7) Preci? rat(大鼠) Zbtb6 (基因ID:366029) qPCR引物对 (全名:zinc finger and BTB domain containing 6;别名:Zfp482,Znf482) Preci? rat(大鼠) Zbtb5 (基因ID:298084) qPCR引物对 (全名:zinc finger and BTB domain containing 5;别名:) Preci? rat(大鼠) Zbtb4 (基因ID:287441) qPCR引物对 (全名:zinc finger and BTB domain containing 4;别名:) Preci? rat(大鼠) Zbtb3 (基因ID:499313) qPCR引物对 (全名:zinc finger and BTB domain containing 3;别名:RGD1561140) Preci? rat(大鼠) Zbtb2 (基因ID:308126) qPCR引物对 (全名:zinc finger and BTB domain containing 2;别名:) Preci? rat(大鼠) Zbtb1 (基因ID:314246) qPCR引物对 (全名:zinc finger and BTB domain containing 1;别名:) Preci? rat(大鼠) Slx4 (基因ID:302953) qPCR引物对 (全名:SLX4 structure-specific endonuclease subunit;别名:Btbd12,RGD1566009) Preci? rat(大鼠) Rhobtb2 (基因ID:306004) qPCR引物对 (全名:Rho-related BTB domain containing 2;别名:) Preci? rat(大鼠) Rhobtb1 (基因ID:309722) qPCR引物对 (全名:Rho-related BTB domain containing 1;别名:) Preci? rat(大鼠) Patz1 (基因ID:305471) qPCR引物对 (全名:POZ (BTB) and AT hook containing zinc finger 1;别名:Zfp278,Znf278) Preci? rat(大鼠) Nacc2 (基因ID:296583) qPCR引物对 (全名:NACC family member 2;别名:Btbd14a) Preci? rat(大鼠) Nacc1 (基因ID:171454) qPCR引物对 (全名:nucleus accumbens associated 1;别名:Nac1,Nac-1,Btbd14b) Preci? rat(大鼠) Mynn (基因ID:361924) qPCR引物对 (全名:myoneurin;别名:) Preci? rat(大鼠) Lgals3bp (基因ID:245955) qPCR引物对 (全名:galectin 3 binding protein;别名:mama,CyCAP,MAC2BP,Ppicap)(tnt9595a) Preci? rat(大鼠) Klhl41 (基因ID:117537) qPCR引物对 (全名:kelch-like family member 41;别名:Krp1,Kbtbd10,Sarcosin) Preci? rat(大鼠) Klhl40 (基因ID:316088) qPCR引物对 (全名:kelch-like family member 40;别名:Kbtbd5) Preci? rat(大鼠) Klhl38 (基因ID:314996) qPCR引物对 (全名:kelch-like family member 38;别名:) Preci? rat(大鼠) Klhl36 (基因ID:498957) qPCR引物对 (全名:kelch-like family member 36;别名:) Preci? rat(大鼠) Klhl35 (基因ID:308850) qPCR引物对 (全名:kelch-like family member 35;别名:RGD1565895) Preci? rat(大鼠) Klhl34 (基因ID:302703) qPCR引物对 (全名:kelch-like family member 34;别名:RGD1560439) Preci? rat(大鼠) Klhl32 (基因ID:313111) qPCR引物对 (全名:kelch-like family member 32;别名:RGD1310364) Preci? rat(大鼠) Klhl31 (基因ID:315833) qPCR引物对 (全名:kelch-like family member 31;别名:RGD1560540) Preci? rat(大鼠) Klhl30 (基因ID:316624) qPCR引物对 (全名:kelch-like family member 30;别名:RGD1309644) Preci? rat(大鼠) Klhl29 (基因ID:298867) qPCR引物对 (全名:kelch-like family member 29;别名:Kbtbd9) Preci? rat(大鼠) Klhl28 (基因ID:299103) qPCR引物对 (全名:kelch-like family member 28;别名:Btbd5) Preci? rat(大鼠) Klhl26 (基因ID:290657) qPCR引物对 (全名:kelch-like family member 26;别名:RGD1312034) Preci? rat(大鼠) Klhl25 (基因ID:293023) qPCR引物对 (全名:kelch-like family member 25;别名:RGD1310815) Preci? rat(大鼠) Klhl24 (基因ID:303803) qPCR引物对 (全名:kelch-like family member 24;别名:Dre1) Preci? rat(大鼠) Klhl23 (基因ID:311114) qPCR引物对 (全名:kelch-like family member 23;别名:RGD1307166) Preci? rat(大鼠) Klhl22 (基因ID:303792) qPCR引物对 (全名:kelch-like family member 22;别名:RGD1306288) Preci? rat(大鼠) Klhl21 (基因ID:313743) qPCR引物对 (全名:kelch-like family member 21;别名:RGD1305863) Preci? rat(大鼠) Klhl20 (基因ID:304920) qPCR引物对 (全名:kelch-like family member 20;别名:RGD1309490) Preci? rat(大鼠) Klhl18 (基因ID:316012) qPCR引物对 (全名:kelch-like family member 18;别名:RGD1310570) Preci? rat(大鼠) Klhl17 (基因ID:246757) qPCR引物对 (全名:kelch-like family member 17;别名:) Preci? rat(大鼠) Klhl15 (基因ID:314111) qPCR引物对 (全名:kelch-like family member 15;别名:RGD1563101) Preci? rat(大鼠) Klhl14 (基因ID:364823) qPCR引物对 (全名:kelch-like family member 14;别名:RGD1566178) Preci? rat(大鼠) Klhl13 (基因ID:313445) qPCR引物对 (全名:kelch-like family member 13;别名:) Preci? rat(大鼠) Klhl12 (基因ID:266772) qPCR引物对 (全名:kelch-like family member 12;别名:C3ip1) Preci? rat(大鼠) Klhl11 (基因ID:287706) qPCR引物对 (全名:kelch-like family member 11;别名:) Preci? rat(大鼠) Klhl10 (基因ID:303533) qPCR引物对 (全名:kelch-like family member 10;别名:) Preci? rat(大鼠) Klhl9 (基因ID:313348) qPCR引物对 (全名:kelch-like family member 9;别名:RGD1304814) Preci? rat(大鼠) Klhl8 (基因ID:289457) qPCR引物对 (全名:kelch-like family member 8;别名:) Preci? rat(大鼠) Klhl7 (基因ID:362303) qPCR引物对 (全名:kelch-like family member 7;别名:) Preci? rat(大鼠) Klhl6 (基因ID:287974) qPCR引物对 (全名:kelch-like family member 6;别名:) Preci? rat(大鼠) Klhl5 (基因ID:305351) qPCR引物对 (全名:kelch-like family member 5;别名:) Preci? rat(大鼠) Klhl4 (基因ID:317196) qPCR引物对 (全名:kelch-like family member 4;别名:RGD1565441) Preci? rat(大鼠) Klhl3 (基因ID:498697) qPCR引物对 (全名:kelch-like family member 3;别名:RGD1565218) Preci? rat(大鼠) Klhl2 (基因ID:290692) qPCR引物对 (全名:kelch-like family member 2;别名:RGD1564686) Preci? rat(大鼠) Klhl1 (基因ID:290426) qPCR引物对 (全名:kelch-like family member 1;别名:) Preci? rat(大鼠) Keap1 (基因ID:117519) qPCR引物对 (全名:Kelch-like ECH-associated protein 1;别名:Inrf2)(tnt9207b) Preci? rat(大鼠) Kctd10 (基因ID:494521) qPCR引物对 (全名:potassium channel tetramerization domain containing 10;别名:) Preci? rat(大鼠) Kctd9 (基因ID:364410) qPCR引物对 (全名:potassium channel tetramerization domain containing 9;别名:) Preci? rat(大鼠) Ivns1abp (基因ID:289089) qPCR引物对 (全名:influenza virus NS1A binding protein;别名:) Preci? rat(大鼠) Ipp (基因ID:298439) qPCR引物对 (全名:intracisternal A particle-promoted polypeptide;别名:) Preci? rat(大鼠) Ibtk (基因ID:315858) qPCR引物对 (全名:inhibitor of Bruton tyrosine kinase;别名:) Preci? rat(大鼠) Hic2 (基因ID:287940) qPCR引物对 (全名:HIC ZBTB transcriptional repressor 2;别名:) Preci? rat(大鼠) Hic1 (基因ID:303310) qPCR引物对 (全名:HIC ZBTB transcriptional repressor 1;别名:) Preci? rat(大鼠) Gzf1 (基因ID:311508) qPCR引物对 (全名:GDNF-inducible zinc finger protein 1;别名:Zfp336,RGD1562321) Preci? rat(大鼠) Gan (基因ID:307893) qPCR引物对 (全名:gigaxonin;别名:) Preci? rat(大鼠) Enc1 (基因ID:294674) qPCR引物对 (全名:ectodermal-neural cortex 1;别名:Nrpb) Preci? rat(大鼠) Bcl6b (基因ID:360551) qPCR引物对 (全名:BCL6B, transcription repressor;别名:RGD1563179) Preci? rat(大鼠) Bcl6 (基因ID:303836) qPCR引物对 (全名:BCL6, transcription repressor;别名:)(tnt9601a) Preci? rat(大鼠) Bach2 (基因ID:313125) qPCR引物对 (全名:BTB domain and CNC homolog 2;别名:RGD1562865) Preci? rat(大鼠) Bach1 (基因ID:304127) qPCR引物对 (全名:BTB domain and CNC homolog 1;别名:) Preci? rat(大鼠) Ankfy1 (基因ID:303292) qPCR引物对 (全名:ankyrin repeat and FYVE domain containing 1;别名:) Preci? rat(大鼠) Abtb3 (基因ID:314675) qPCR引物对 (全名:ankyrin repeat and BTB domain containing 3;别名:Btbd11) Preci? rat(大鼠) Abtb2 (基因ID:171440) qPCR引物对 (全名:ankyrin repeat and BTB domain containing 2;别名:Cca3) Preci? rat(大鼠) Abtb1 (基因ID:297432) qPCR引物对 (全名:ankyrin repeat and BTB domain containing 1;别名:) Preci? rat(大鼠) Tnfaip1 (基因ID:287543) qPCR引物对 (全名:TNF alpha induced protein 1;别名:Edp1) Preci? rat(大鼠) Spopl (基因ID:296532) qPCR引物对 (全名:speckle type BTB/POZ protein like;别名:RGD1305847) Preci? rat(大鼠) Spop (基因ID:287643) qPCR引物对 (全名:speckle type BTB/POZ protein;别名:) Preci? rat(大鼠) Rhobtb3 (基因ID:309922) qPCR引物对 (全名:Rho-related BTB domain containing 3;别名:) Preci? rat(大鼠) Rcbtb2 (基因ID:290363) qPCR引物对 (全名:RCC1 and BTB domain containing protein 2;别名:Chc1l) Preci? rat(大鼠) Rcbtb1 (基因ID:361050) qPCR引物对 (全名:RCC1 and BTB domain containing protein 1;别名:) Preci? rat(大鼠) Lztr1 (基因ID:360745) qPCR引物对 (全名:leucine zipper like post translational regulator 1;别名:) Preci? rat(大鼠) Kbtbd12 (基因ID:502859) qPCR引物对 (全名:kelch repeat and BTB domain containing 12;别名:) Preci? rat(大鼠) Kbtbd11 (基因ID:306617) qPCR引物对 (全名:kelch repeat and BTB domain containing 11;别名:RGD1563576) Preci? rat(大鼠) Kbtbd8 (基因ID:500262) qPCR引物对 (全名:kelch repeat and BTB domain containing 8;别名:RGD1563166) Preci? rat(大鼠) Nupr1 (基因ID:101000000) qPCR引物对 (全名:nuclear protein 1, transcriptional regulator;别名:p8,Nupr1l1) Preci? rat(大鼠) Kbtbd6 (基因ID:306073) qPCR引物对 (全名:kelch repeat and BTB domain containing 6;别名:) Preci? rat(大鼠) Kbtbd4 (基因ID:311185) qPCR引物对 (全名:kelch repeat and BTB domain containing 4;别名:) Preci? rat(大鼠) Kbtbd3 (基因ID:315394) qPCR引物对 (全名:kelch repeat and BTB domain containing 3;别名:) Preci? rat(大鼠) Kbtbd2 (基因ID:312372) qPCR引物对 (全名:kelch repeat and BTB domain containing 2;别名:) Preci? rat(大鼠) Gmcl1 (基因ID:312516) qPCR引物对 (全名:germ cell-less 1, spermatogenesis associated;别名:Gcl) Preci? rat(大鼠) Ccin (基因ID:298392) qPCR引物对 (全名:calicin;别名:) Preci? rat(大鼠) Fosb (基因ID:100000000) qPCR引物对 (全名:FosB proto-oncogene, AP-1 transcription factor subunit;别名:fra-2) Preci? rat(大鼠) Fosb (基因ID:100000000) qPCR引物对 (全名:FosB proto-oncogene, AP-1 transcription factor subunit;别名:fra-2) Preci? rat(大鼠) Btbd17 (基因ID:303660) qPCR引物对 (全名:BTB domain containing 17;别名:RGD1563331) Preci? rat(大鼠) Btbd16 (基因ID:361658) qPCR引物对 (全名:BTB domain containing 16;别名:RGD1311454) Preci? rat(大鼠) Btbd10 (基因ID:308890) qPCR引物对 (全名:BTB domain containing 10;别名:RGD1306301) Preci? rat(大鼠) Btbd9 (基因ID:294318) qPCR引物对 (全名:BTB domain containing 9;别名:) Preci? rat(大鼠) Fosb (基因ID:100000000) qPCR引物对 (全名:FosB proto-oncogene, AP-1 transcription factor subunit;别名:fra-2) Preci? rat(大鼠) Btbd7 (基因ID:362772) qPCR引物对 (全名:BTB domain containing 7;别名:) Preci? rat(大鼠) Btbd6 (基因ID:690367) qPCR引物对 (全名:BTB domain containing 6;别名:) Preci? rat(大鼠) Btbd3 (基因ID:311462) qPCR引物对 (全名:BTB domain containing 3;别名:) Preci? rat(大鼠) Btbd2 (基因ID:500793) qPCR引物对 (全名:BTB domain containing 2;别名:RGD1566094) Preci? rat(大鼠) Btbd1 (基因ID:293060) qPCR引物对 (全名:BTB domain containing 1;别名:)
“包含BTB域”的基因群是一类具有共同特征的基因,这些基因编码的蛋白质中都含有BTB(Broad-Complex, Tramtrack, Bric-a-brac)结构域。以下是对这一基因群的详细分析和归纳:
BTB结构域的定义:
BTB结构域是一种蛋白间相互作用模块,约含120个氨基酸,最初在果蝇蛋白Broad-complex、Tramtrack和Bric-abrac中被发现。它也被称为POZ(Poxvirus and Zinc finger)结构域,常见于多种锌指转录因子和Shaw型钾离子通道蛋白的氨基末端。
BTB结构域的功能:
BTB结构域通过局部调控染色质构象来调节基因表达。在多种情况下,它调控蛋白低聚化,从而防止高亲和力地结合DNA。
BTB结构域能形成二聚体,并介导与不含BTB结构域的蛋白之间的相互作用,实现蛋白间的特异性结合。
包含BTB域的基因群成员:
ZBTB12:编码一种含锌指和BTB域12的蛋白质,预计参与RNA聚合酶II的转录调控,并在卵巢、子宫内膜等组织中广泛表达。
KBTBD2:编码一种Kelch repeat和BTB(POZ) domain containing 2的蛋白质,该蛋白质是潜在的药物靶点或生物标志物,与DNA结合活性密切相关。
BTBD6:定位于人类染色体14号长臂3区2带,含有BTB、BACK、PHR三个结构域,但其具体功能尚未阐明。
BTBD1(或称为BTB/POZ结构域蛋白1):与丙型肝炎病毒的NS5A反转录蛋白8相关,是细胞生物、细胞周期蛋白、转录调节因子、细菌及病毒、细胞分化等领域的研究对象。
数字信息:
ZBTB12:基因ID为221527,有1个转录本(splice variant)、1个基因等位基因、158个直系同源基因(orthologues)和28个旁系同源基因(paralogues)。
KBTBD2:基因编码的蛋白质分子在细胞内具有重要生物学功能,是药物研发的重要靶点。
BTBD6:蛋白质的计算分子量为45.69kDa,由410个氨基酸残基组成。
BTBD1:预测的蛋白质分子量为53kDa。
总结:
“包含BTB域”的基因群编码的蛋白质在细胞信号传导、基因表达调控、蛋白质相互作用等生物过程中发挥重要作用。这些蛋白质的功能异常可能与多种疾病的发生和发展相关,因此是生物医学研究和药物开发的重要目标。