产品参数
Preci? human(人) WRNIP1 (基因ID:56897) qPCR引物对 (全名:WRN helicase interacting protein 1;别名:WHIP,FAP93,CFAP93,bA420G6.2) Preci? human(人) WDR93 (基因ID:56964) qPCR引物对 (全名:WD repeat domain 93;别名:C1d-87,FAP297,CFAP297) Preci? human(人) WDR5 (基因ID:11091) qPCR引物对 (全名:WD repeat domain 5;别名:BIG3,SWD3,BIG-3,CFAP89) Preci? human(人) WBP11 (基因ID:51729) qPCR引物对 (全名:WW domain binding protein 11;别名:BUG13,FAP90,NPWBP,SIPP1,VCTRL,CFAP90,VCTERL,WBP-11,PPP1R165) Preci? human(人) UBA1 (基因ID:7317) qPCR引物对 (全名:ubiquitin like modifier activating enzyme 1;别名:A1S9,A1ST,GXP1,UBE1,A1S9T,AMCX1,POC20,SMAX2,UBA1A,UBE1X,VEXAS,CFAP124) Preci? human(人) TNNC2 (基因ID:7125) qPCR引物对 (全名:troponin C2, fast skeletal type;别名:FAP85,CFAP85,CMYP15,MYONRI) Preci? human(人) SPAG6 (基因ID:9576) qPCR引物对 (全名:sperm associated antigen 6;别名:pf16,CT141,FAP194,CFAP194,Repro-SA-1) Preci? human(人) RASSF7 (基因ID:8045) qPCR引物对 (全名:Ras association domain family member 7;别名:HRC1,FAP88,HRAS1,CFAP88,C11orf13) Preci? human(人) PPP4R4 (基因ID:57718) qPCR引物对 (全名:protein phosphatase 4 regulatory subunit 4;别名:PP4R4,CFAP14,KIAA1622) Preci? human(人) PPP1R11 (基因ID:6992) qPCR引物对 (全名:protein phosphatase 1 regulatory inhibitor subunit 11;别名:HCGV,IPP3,HCG-V,TCTE5,TCTEX5,CFAP255) Preci? human(人) NPHP3 (基因ID:27031) qPCR引物对 (全名:nephrocystin 3;别名:MKS7,NPH3,RHPD,RHPD1,SLSN3,CFAP31) Preci? human(人) NME7 (基因ID:29922) qPCR引物对 (全名:NME/NM23 family member 7;别名:NDK7,NDK 7,CFAP67,MN23H7,nm23-H7) Preci? human(人) ITPR2 (基因ID:3709) qPCR引物对 (全名:inositol 1,4,5-trisphosphate receptor type 2;别名:ANHD,IP3R2,CFAP48,INSP3R2)(tnt6685b) Preci? human(人) IQCG (基因ID:84223) qPCR引物对 (全名:IQ motif containing G;别名:DRC9,CFAP122) Preci? human(人) IQCD (基因ID:115811) qPCR引物对 (全名:IQ motif containing D;别名:DRC10,CFAP84,4933433C09Rik) Preci? human(人) IFT46 (基因ID:56912) qPCR引物对 (全名:intraflagellar transport 46;别名:FAP32,CFAP32,C11orf2,C11orf60) Preci? human(人) GOLGA8A (基因ID:23015) qPCR引物对 (全名:golgin A8 family member A;别名:GM88,FAP286,CFAP286,GOLGA8B) Preci? human(人) FBXL13 (基因ID:222235) qPCR引物对 (全名:F-box and leucine rich repeat protein 13;别名:DRC6,Fbl13,CFAP169) Preci? human(人) EFHB (基因ID:151651) qPCR引物对 (全名:EF-hand domain family member B;别名:CFAP21) Preci? human(人) EFCAB2 (基因ID:84288) qPCR引物对 (全名:EF-hand calcium binding domain 2;别名:DRC8,CFAP200) Preci? human(人) DYNC2I2 (基因ID:89891) qPCR引物对 (全名:dynein 2 intermediate chain 2;别名:DIC5,WDR34,FAP133,SRTD11,CFAP133,bA216B9.3) Preci? human(人) DYNC2I1 (基因ID:55112) qPCR引物对 (全名:dynein 2 intermediate chain 1;别名:DIC6,SRPS6,SRTD8,WDR60,FAP163,CFAP163) Preci? human(人) DRC7 (基因ID:84229) qPCR引物对 (全名:dynein regulatory complex subunit 7;别名:FAP50,CFAP50,CCDC135,C16orf50) Preci? human(人) DRC3 (基因ID:83450) qPCR引物对 (全名:dynein regulatory complex subunit 3;别名:LRRC48,CFAP134) Preci? human(人) CTCF (基因ID:10664) qPCR引物对 (全名:CCCTC-binding factor;别名:MRD21,FAP108,CFAP108)(tnt9780a) Preci? human(人) COP1 (基因ID:64326) qPCR引物对 (全名:COP1 E3 ubiquitin ligase;别名:FAP78,RFWD2,CFAP78,RNF200)(tnt5581a) Preci? human(人) CLUAP1 (基因ID:23059) qPCR引物对 (全名:clusterin associated protein 1;别名:FAP22,IFT38,CFAP22) Preci? human(人) CFAP298 (基因ID:56683) qPCR引物对 (全名:cilia and flagella associated protein 298;别名:Kur,FBB18,CILD26,DNAAF16,C21orf48,C21orf59) Preci? human(人) CFAP70 (基因ID:118491) qPCR引物对 (全名:cilia and flagella associated protein 70;别名:TTC18,SPGF41) Preci? human(人) CFAP69 (基因ID:79846) qPCR引物对 (全名:cilia and flagella associated protein 69;别名:FAP69,SPGF24,C7orf63) Preci? human(人) CFAP57 (基因ID:149465) qPCR引物对 (全名:cilia and flagella associated protein 57;别名:VWS2,WDR65) Preci? human(人) CFAP52 (基因ID:146845) qPCR引物对 (全名:cilia and flagella associated protein 52;别名:HTX10,WDR16,WDRPUH) Preci? human(人) CFAP46 (基因ID:54777) qPCR引物对 (全名:cilia and flagella associated protein 46;别名:TTC40,C10orf92,C10orf93,C10orf123,C10orf124,bA288G11.4,bA288G11.5,bB137A17.2,bB137A17.3) Preci? human(人) CFAP44 (基因ID:55779) qPCR引物对 (全名:cilia and flagella associated protein 44;别名:WDR52,SPGF20) Preci? human(人) CFAP43 (基因ID:80217) qPCR引物对 (全名:cilia and flagella associated protein 43;别名:WDR96,HYDNP1,SPGF19,C10orf79,bA373N18.2) Preci? human(人) CEP104 (基因ID:9731) qPCR引物对 (全名:centrosomal protein 104;别名:GlyBP,MRT77,ROC22,JBTS25,CFAP256,KIAA0562) Preci? human(人) CDKL5 (基因ID:6792) qPCR引物对 (全名:cyclin dependent kinase like 5;别名:DEE2,ISSX,STK9,EIEE2,CFAP247) Preci? human(人) CCDC65 (基因ID:85478) qPCR引物对 (全名:coiled-coil domain containing 65;别名:DRC2,FAP250,CFAP250,NYD-SP28) Preci? human(人) CCDC40 (基因ID:55036) qPCR引物对 (全名:coiled-coil domain 40 molecular ruler complex subunit;别名:CILD15,FAP172,CFAP172) Preci? human(人) ATP2B3 (基因ID:492) qPCR引物对 (全名:ATPase plasma membrane Ca2+ transporting 3;别名:CLA2,OPCA,PMCA3,SCAX1,CFAP39,PMCA3a)(tnt6674b) Preci? human(人) ANKRD28 (基因ID:23243) qPCR引物对 (全名:ankyrin repeat domain 28;别名:PITK,FAP79,CFAP79,PPP1R65) Preci? human(人) ANK2 (基因ID:287) qPCR引物对 (全名:ankyrin 2;别名:LQT4,ANK-2,FAP87,CFAP87,brank-2) Preci? human(人) AK7 (基因ID:122481) qPCR引物对 (全名:adenylate kinase 7;别名:AK 7,FAP75,CFAP75,SPGF27) Preci? human(人) SPATA17 (基因ID:128153) qPCR引物对 (全名:spermatogenesis associated 17;别名:IQCH,MOT17,FAP305,MSRG11,CFAP305,MSRG-11) Preci? human(人) SPATA4 (基因ID:132851) qPCR引物对 (全名:spermatogenesis associated 4;别名:FAP178,SPEF1B,TSARG2,CFAP178) Preci? human(人) PTRH2 (基因ID:51651) qPCR引物对 (全名:peptidyl-tRNA hydrolase 2;别名:PTH,BIT1,PTH2,PTH 2,CFAP37,IMNEPD,CGI-147) Preci? human(人) PPIP5K2 (基因ID:23262) qPCR引物对 (全名:diphosphoinositol pentakisphosphate kinase 2;别名:VIP2,IP7K2,CFAP160,DFNB100,HISPPD1) Preci? human(人) MMAB (基因ID:326625) qPCR引物对 (全名:metabolism of cobalamin associated B;别名:ATR,cob,cblB,CFAP23) Preci? human(人) LRRC72 (基因ID:100506049) qPCR引物对 (全名:leucine rich repeat containing 72;别名:FAP279,CFAP279) Preci? human(人) LRGUK (基因ID:136332) qPCR引物对 (全名:leucine rich repeats and guanylate kinase domain containing;别名:CFAP246) Preci? human(人) ENKUR (基因ID:219670) qPCR引物对 (全名:enkurin, TRPC channel interacting protein;别名:CFAP106,C10orf63) Preci? human(人) EDF1 (基因ID:8721) qPCR引物对 (全名:endothelial differentiation related factor 1;别名:MBF1,EDF-1,CFAP280) Preci? human(人) DLEC1 (基因ID:9940) qPCR引物对 (全名:DLEC1 cilia and flagella associated protein;别名:F56,DLC1,DLC-1,FAP81,CFAP81) Preci? human(人) CFAP300 (基因ID:85016) qPCR引物对 (全名:cilia and flagella associated protein 300;别名:FBB5,CILD38,DNAAF17,C11orf70) Preci? human(人) CFAP299 (基因ID:255119) qPCR引物对 (全名:cilia and flagella associated protein 299;别名:C4orf22) Preci? human(人) CFAP221 (基因ID:200373) qPCR引物对 (全名:cilia and flagella associated protein 221;别名:PCDP1,FAP221) Preci? human(人) CFAP206 (基因ID:154313) qPCR引物对 (全名:cilia and flagella associated protein 206;别名:C6orf165,dJ382I10.1) Preci? human(人) CFAP161 (基因ID:161502) qPCR引物对 (全名:cilia and flagella associated protein 161;别名:C15orf26) Preci? human(人) CFAP157 (基因ID:286207) qPCR引物对 (全名:cilia and flagella associated protein 157;别名:C9orf117) Preci? human(人) CFAP126 (基因ID:257177) qPCR引物对 (全名:cilia and flagella associated protein 126;别名:Fltp,Flattop,C1orf192) Preci? human(人) CFAP100 (基因ID:348807) qPCR引物对 (全名:cilia and flagella associated protein 100;别名:MIA1,CCDC37) Preci? human(人) CFAP99 (基因ID:402160) qPCR引物对 (全名:cilia and flagella associated protein 99;别名:) Preci? human(人) CFAP97 (基因ID:57587) qPCR引物对 (全名:cilia and flagella associated protein 97;别名:hmw,KIAA1430) Preci? human(人) CFAP77 (基因ID:389799) qPCR引物对 (全名:cilia and flagella associated protein 77;别名:C9orf171) Preci? human(人) CFAP74 (基因ID:85452) qPCR引物对 (全名:cilia and flagella associated protein 74;别名:CILD49,C1orf222,KIAA1751) Preci? human(人) CFAP73 (基因ID:387885) qPCR引物对 (全名:cilia and flagella associated protein 73;别名:MIA2,CCDC42B) Preci? human(人) CFAP65 (基因ID:255101) qPCR引物对 (全名:cilia and flagella associated protein 65;别名:SPGF40,CCDC108) Preci? human(人) CFAP61 (基因ID:26074) qPCR引物对 (全名:cilia and flagella associated protein 61;别名:SPGF84,CaM-IP3,C20orf26,dJ1002M8.3,dJ1178H5.4) Preci? human(人) CFAP58 (基因ID:159686) qPCR引物对 (全名:cilia and flagella associated protein 58;别名:SPGF49,CCDC147,C10orf80,bA127L20.4,bA127L20.5,bA554P13.1) Preci? human(人) CFAP54 (基因ID:144535) qPCR引物对 (全名:cilia and flagella associated protein 54;别名:C12orf55,C12orf63) Preci? human(人) CFAP53 (基因ID:220136) qPCR引物对 (全名:cilia and flagella associated protein 53;别名:HTX6,CCDC11) Preci? human(人) CFAP47 (基因ID:286464) qPCR引物对 (全名:cilia and flagella associated protein 47;别名:CHDC2,SPGF52,SPGFX3,CXorf22,CXorf30,CXorf59) Preci? human(人) CFAP45 (基因ID:25790) qPCR引物对 (全名:cilia and flagella associated protein 45;别名:HTX11,NESG1,CCDC19) Preci? human(人) CFAP36 (基因ID:112942) qPCR引物对 (全名:cilia and flagella associated protein 36;别名:BARTL1,CCDC104) Preci? human(人) CFAP20 (基因ID:29105) qPCR引物对 (全名:cilia and flagella associated protein 20;别名:GTL3,BUG22,EVORF,fSAP23,C16orf80) Preci? human(人) CCDC180 (基因ID:100499483) qPCR引物对 (全名:coiled-coil domain containing 180;别名:FAP76,CFAP76,C9orf174) Preci? human(人) CCDC39 (基因ID:339829) qPCR引物对 (全名:coiled-coil domain 39 molecular ruler complex subunit;别名:FAP59,CFAP59,CILD14)
“纤毛和鞭毛相关”基因群主要涉及编码参与纤毛(cilia)和鞭毛(flagella)形成、结构、功能以及调控的蛋白质的基因。纤毛和鞭毛是真核细胞表面的一类重要细胞器,普遍存在于多种细胞中,包括精子细胞、气管上皮细胞等,它们在细胞运动、信号转导、胚胎发育等过程中发挥关键作用。
以下是对“纤毛和鞭毛相关”基因群的清晰概述:
纤毛和鞭毛的结构与功能:
纤毛和鞭毛主要由微管(microtubules)构成,其骨架结构具有“9+2”的微管排列方式,即中心两根单微管周围环绕九根双联微管。
它们能够通过ATP水解产生的能量进行自主运动,推动细胞表面的液体流动或参与细胞运动,如精子游动。
相关基因的功能:
结构蛋白:编码构成纤毛和鞭毛骨架的微管蛋白、连接蛋白等,如动力蛋白(dynein)及其重链、中链和轻链,它们参与纤毛和鞭毛的运动。
调控蛋白:编码调控纤毛和鞭毛生长、运动以及稳定性的蛋白质,这些蛋白对于维持纤毛和鞭毛的正常功能至关重要。
特定基因与疾病:
纤毛和鞭毛相关基因的突变或异常表达可能导致多种遗传性疾病,如原发性纤毛运动障碍症(PCD),表现为呼吸道纤毛粘液清除障碍、慢性呼吸道感染、内脏异位、先天性心脏病等。
近年来的研究已经鉴定出了一些与纤毛和鞭毛结构或功能密切相关的基因,如Pierce1/Pierce2等,这些基因的缺失或突变可能导致纤毛运动障碍。
研究进展:
随着基因测序技术和结构生物学分析方法的进步,越来越多的纤毛和鞭毛相关基因被鉴定出来,这为深入理解纤毛和鞭毛的生物学功能以及相关疾病的发病机制提供了重要基础。
通过构建基因敲除动物模型,研究人员能够更直接地研究这些基因在纤毛和鞭毛形成、功能以及疾病中的作用。
总之,“纤毛和鞭毛相关”基因群是一个庞大而复杂的基因集合,它们共同参与了纤毛和鞭毛的形成、结构、功能以及调控。对这些基因的研究不仅有助于我们深入理解纤毛和鞭毛的生物学特性,还有助于开发针对相关疾病的治疗策略。