产品参数
Preci? human(人) SREBF2 (基因ID:6721) qPCR引物对 (全名:sterol regulatory element binding transcription factor 2;别名:SREBP2,bHLHd2,SREBP-2)(tnt5160a) Preci? human(人) SREBF1 (基因ID:6720) qPCR引物对 (全名:sterol regulatory element binding transcription factor 1;别名:HMD,IFAP2,SREBP1,bHLHd1)(tnt3391b) Preci? human(人) SIM2 (基因ID:6493) qPCR引物对 (全名:SIM bHLH transcription factor 2;别名:SIM,bHLHe15,HMC13F06,HMC29C01) Preci? human(人) SIM1 (基因ID:6492) qPCR引物对 (全名:SIM bHLH transcription factor 1;别名:bHLHe14) Preci? human(人) PTF1A (基因ID:256297) qPCR引物对 (全名:pancreas associated transcription factor 1a;别名:p48,PACA,PAGEN2,bHLHa29,PTF1-p48) Preci? human(人) NPAS4 (基因ID:266743) qPCR引物对 (全名:neuronal PAS domain protein 4;别名:NXF,Le-PAS,PASD10,bHLHe79) Preci? human(人) NPAS3 (基因ID:64067) qPCR引物对 (全名:neuronal PAS domain protein 3;别名:MOP6,PASD6,bHLHe12)(tnt6005a) Preci? human(人) NPAS2 (基因ID:4862) qPCR引物对 (全名:neuronal PAS domain protein 2;别名:MOP4,PASD4,bHLHe9)(tnt7835a) Preci? human(人) NPAS1 (基因ID:4861) qPCR引物对 (全名:neuronal PAS domain protein 1;别名:MOP5,PASD5,bHLHe11) Preci? human(人) NCOA3 (基因ID:8202) qPCR引物对 (全名:nuclear receptor coactivator 3;别名:ACTR,AIB1,RAC3,SRC3,pCIP,AIB-1,CTG26,SRC-3,CAGH16,KAT13B,TNRC14,TNRC16,TRAM-1,bHLHe42)(tnt10085a) Preci? human(人) NCOA2 (基因ID:10499) qPCR引物对 (全名:nuclear receptor coactivator 2;别名:SRC2,TIF2,GRIP1,KAT13C,NCoA-2,bHLHe75) Preci? human(人) NCOA1 (基因ID:8648) qPCR引物对 (全名:nuclear receptor coactivator 1;别名:SRC1,KAT13A,RIP160,F-SRC-1,bHLHe42,bHLHe74) Preci? human(人) MYOG (基因ID:4656) qPCR引物对 (全名:myogenin;别名:MYF4,myf-4,bHLHc3) Preci? human(人) MYOD1 (基因ID:4654) qPCR引物对 (全名:myogenic differentiation 1;别名:PUM,MYF3,MYOD,CMYP17,bHLHc1,MYODRIF)(tnt10129a) Preci? human(人) MYF6 (基因ID:4618) qPCR引物对 (全名:myogenic factor 6;别名:CNM3,MRF4,myf-6,bHLHc4) Preci? human(人) MYF5 (基因ID:4617) qPCR引物对 (全名:myogenic factor 5;别名:EORVA,bHLHc2) Preci? human(人) MXI1 (基因ID:4601) qPCR引物对 (全名:MAX interactor 1, dimerization protein;别名:MXI,MAD2,MXD2,bHLHc11)(c010a) Preci? human(人) MXD4 (基因ID:10608) qPCR引物对 (全名:MAX dimerization protein 4;别名:MAD4,MST149,MSTP149,bHLHc12) Preci? human(人) MXD3 (基因ID:83463) qPCR引物对 (全名:MAX dimerization protein 3;别名:MYX,MAD3,BHLHC13) Preci? human(人) MXD1 (基因ID:4084) qPCR引物对 (全名:MAX dimerization protein 1;别名:MAD,MAD1,BHLHC58) Preci? human(人) MNT (基因ID:4335) qPCR引物对 (全名:MAX network transcriptional repressor;别名:ROX,MAD6,MXD6,bHLHd3,lncRNA-HAL) Preci? human(人) MLX (基因ID:6945) qPCR引物对 (全名:MAX dimerization protein MLX;别名:TF4,MAD7,MXD7,TCFL4,bHLHd13) Preci? human(人) HIF3A (基因ID:64344) qPCR引物对 (全名:hypoxia inducible factor 3 subunit alpha;别名:IPAS,MOP7,PASD7,HIF-3A,bHLHe17,HIF3-alpha-1)(tnt6810b) Preci? human(人) HIF1A (基因ID:3091) qPCR引物对 (全名:hypoxia inducible factor 1 subunit alpha;别名:HIF1,MOP1,PASD8,HIF-1A,bHLHe78,HIF-1alpha,HIF1-ALPHA,HIF-1-alpha)(tnt5457a) Preci? human(人) EPAS1 (基因ID:2034) qPCR引物对 (全名:endothelial PAS domain protein 1;别名:HLF,MOP2,ECYT4,HIF2A,PASD2,bHLHe73)(tnt2212b) Preci? human(人) CLOCK (基因ID:9575) qPCR引物对 (全名:clock circadian regulator;别名:KAT13D,bHLHe8)(tnt5642a) Preci? human(人) BMAL2 (基因ID:56938) qPCR引物对 (全名:basic helix-loop-helix ARNT like 2;别名:CLIF,MOP9,PASD9,ARNTL2,bHLHe6) Preci? human(人) BMAL1 (基因ID:406) qPCR引物对 (全名:basic helix-loop-helix ARNT like 1;别名:TIC,JAP3,MOP3,ARNTL,PASD3,ARNTL1,BMAL1c,bHLHe5)(tnt5640a) Preci? human(人) ARNT2 (基因ID:9915) qPCR引物对 (全名:aryl hydrocarbon receptor nuclear translocator 2;别名:WEDAS,bHLHe1) Preci? human(人) ARNT (基因ID:405) qPCR引物对 (全名:aryl hydrocarbon receptor nuclear translocator;别名:ARNT1,HIF1B,TANGO,bHLHe2,HIF1BETA,HIF-1beta,HIF1-beta,HIF-1-beta)(tnt6811b) Preci? human(人) AHRR (基因ID:57491) qPCR引物对 (全名:aryl hydrocarbon receptor repressor;别名:AHH,AHHR,bHLHe77) Preci? human(人) AHR (基因ID:196) qPCR引物对 (全名:aryl hydrocarbon receptor;别名:RP85,bHLHe76)(tnt7644a) Preci? human(人) USF2 (基因ID:7392) qPCR引物对 (全名:upstream transcription factor 2, c-fos interacting;别名:FIP,bHLHb12) Preci? human(人) USF1 (基因ID:7391) qPCR引物对 (全名:upstream transcription factor 1;别名:UEF,FCHL,MLTF,FCHL1,MLTFI,HYPLIP1,bHLHb11) Preci? human(人) TWIST2 (基因ID:117581) qPCR引物对 (全名:twist family bHLH transcription factor 2;别名:AMS,FFDD3,BBRSAY,DERMO1,SETLSS,bHLHa39)(tnt7443b) Preci? human(人) TWIST1 (基因ID:7291) qPCR引物对 (全名:twist family bHLH transcription factor 1;别名:CRS,CSO,SCS,ACS3,CRS1,BPES2,BPES3,SWCOS,TWIST,bHLHa38)(tnt6247c) Preci? human(人) TFEC (基因ID:22797) qPCR引物对 (全名:transcription factor EC;别名:TCFEC,TFE-C,TFECL,TFEC-L,bHLHe34,hTFEC-L) Preci? human(人) TFEB (基因ID:7942) qPCR引物对 (全名:transcription factor EB;别名:TCFEB,BHLHE35,ALPHATFEB)(tnt4816a) Preci? human(人) TFE3 (基因ID:7030) qPCR引物对 (全名:transcription factor binding to IGHM enhancer 3;别名:TFEA,RCCP2,RCCX1,MRXSPF,bHLHe33) Preci? human(人) TFAP4 (基因ID:7023) qPCR引物对 (全名:transcription factor AP-4;别名:AP-4,bHLHc41) Preci? human(人) TCFL5 (基因ID:10732) qPCR引物对 (全名:transcription factor like 5;别名:CHA,Figlb,SOSF1,E2BP-1,bHLHe82) Preci? human(人) TCF24 (基因ID:100129654) qPCR引物对 (全名:transcription factor 24;别名:TCF-24,bHLHa25) Preci? human(人) TCF23 (基因ID:150921) qPCR引物对 (全名:transcription factor 23;别名:OUT,TCF-23,bHLHa24) Preci? human(人) TCF21 (基因ID:6943) qPCR引物对 (全名:transcription factor 21;别名:POD1,bHLHa23) Preci? human(人) TCF15 (基因ID:6939) qPCR引物对 (全名:transcription factor 15;别名:EC2,PARAXIS,bHLHa40)(tnt3775b) Preci? human(人) TCF12 (基因ID:6938) qPCR引物对 (全名:transcription factor 12;别名:HEB,p64,CRS3,HH26,HTF4,TCF-12,bHLHb20,HsT17266)(tnt9579a) Preci? human(人) TCF4 (基因ID:6925) qPCR引物对 (全名:transcription factor 4;别名:E2-2,FCD2,ITF2,PTHS,SEF2,CDG2T,FECD3,ITF-2,SEF-2,TCF-4,SEF2-1,SEF2-1A,SEF2-1B,SEF2-1D,bHLHb19)(tnt1407) Preci? human(人) TCF3 (基因ID:6929) qPCR引物对 (全名:transcription factor 3;别名:E2A,E47,p75,AGM8,ITF1,VDIR,AGM8A,AGM8B,TCF-3,bHLHb21)(tnt1557b) Preci? human(人) TAL2 (基因ID:6887) qPCR引物对 (全名:TAL bHLH transcription factor 2;别名:) Preci? human(人) TAL1 (基因ID:6886) qPCR引物对 (全名:TAL bHLH transcription factor 1, erythroid differentiation factor;别名:SCL,TCL5,tal-1,bHLHa17) Preci? human(人) SOHLH2 (基因ID:54937) qPCR引物对 (全名:spermatogenesis and oogenesis specific basic helix-loop-helix 2;别名:TEB1,SOSF2,SPATA28,bHLHe81) Preci? human(人) SOHLH1 (基因ID:402381) qPCR引物对 (全名:spermatogenesis and oogenesis specific basic helix-loop-helix 1;别名:ODG5,TEB2,NOHLH,SPGF32,SPATA27,bHLHe80,C9orf157,bA100C15.3) Preci? human(人) SCX (基因ID:642658) qPCR引物对 (全名:scleraxis bHLH transcription factor;别名:SCXA,SCXB,bHLHa48) Preci? human(人) OLIG3 (基因ID:167826) qPCR引物对 (全名:oligodendrocyte transcription factor 3;别名:Bhlhb7,bHLHe20) Preci? human(人) OLIG2 (基因ID:10215) qPCR引物对 (全名:oligodendrocyte transcription factor 2;别名:BHLHB1,OLIGO2,RACK17,PRKCBP2,bHLHe19) Preci? human(人) OLIG1 (基因ID:116448) qPCR引物对 (全名:oligodendrocyte transcription factor 1;别名:BHLHB6,BHLHE21) Preci? human(人) NHLH2 (基因ID:4808) qPCR引物对 (全名:nescient helix-loop-helix 2;别名:HEN2,HH27,NSCL2,bHLHa34) Preci? human(人) NHLH1 (基因ID:4807) qPCR引物对 (全名:nescient helix-loop-helix 1;别名:HEN1,NSCL,NSCL1,bHLHa35) Preci? human(人) NEUROG3 (基因ID:50674) qPCR引物对 (全名:neurogenin 3;别名:ngn3,Atoh5,NGN-3,Math4B,bHLHa7) Preci? human(人) NEUROG2 (基因ID:63973) qPCR引物对 (全名:neurogenin 2;别名:NGN2,Atoh4,ngn-2,Math4A,bHLHa8) Preci? human(人) NEUROG1 (基因ID:4762) qPCR引物对 (全名:neurogenin 1;别名:AKA,ngn1,CCDDRD,Math4C,bHLHa6,NEUROD3) Preci? human(人) NEUROD6 (基因ID:63974) qPCR引物对 (全名:neuronal differentiation 6;别名:Nex1,Atoh2,MATH2,NEX1M,Math-2,bHLHa2) Preci? human(人) NEUROD4 (基因ID:58158) qPCR引物对 (全名:neuronal differentiation 4;别名:ATH3,ATH-3,Atoh3,MATH3,MATH-3,bHLHa4) Preci? human(人) NEUROD2 (基因ID:4761) qPCR引物对 (全名:neuronal differentiation 2;别名:NDRF,DEE72,EIEE72,bHLHa1)(tnt8791a) Preci? human(人) NEUROD1 (基因ID:4760) qPCR引物对 (全名:neuronal differentiation 1;别名:T2D,BETA2,BHF-1,MODY6,NEUROD,bHLHa3) Preci? human(人) MYCN (基因ID:4613) qPCR引物对 (全名:MYCN proto-oncogene, bHLH transcription factor;别名:NMYC,ODED,MODED,MPAPA,N-myc,FGLDS1,bHLHe37,MYCNsORF,MYCNsPEP)(tnt3717b) Preci? human(人) MYCL (基因ID:4610) qPCR引物对 (全名:MYCL proto-oncogene, bHLH transcription factor;别名:LMYC,L-Myc,MYCL1,bHLHe38)(tnt6997b) Preci? human(人) MYC (基因ID:4609) qPCR引物对 (全名:MYC proto-oncogene, bHLH transcription factor;别名:MRTL,MYCC,c-Myc,bHLHe39)(tnt5255b) Preci? human(人) MSC (基因ID:9242) qPCR引物对 (全名:musculin;别名:ABF1,MYOR,ABF-1,bHLHa22) Preci? human(人) MLXIPL (基因ID:51085) qPCR引物对 (全名:MLX interacting protein like;别名:MIO,MLX,CHREBP,MONDOB,WBSCR14,WS-bHLH,bHLHd14)(tnt5988b) Preci? human(人) MLXIP (基因ID:22877) qPCR引物对 (全名:MLX interacting protein;别名:MIR,MONDOA,bHLHe36) Preci? human(人) MITF (基因ID:4286) qPCR引物对 (全名:melanocyte inducing transcription factor;别名:MI,WS2,CMM8,WS2A,COMMAD,MITF-A,bHLHe32)(tnt7318a) Preci? human(人) MESP2 (基因ID:145873) qPCR引物对 (全名:mesoderm posterior bHLH transcription factor 2;别名:SCDO2,bHLHc6) Preci? human(人) MESP1 (基因ID:55897) qPCR引物对 (全名:mesoderm posterior bHLH transcription factor 1;别名:bHLHc5) Preci? human(人) MAX (基因ID:4149) qPCR引物对 (全名:MYC associated factor X;别名:PDMCS,bHLHd4) Preci? human(人) LYL1 (基因ID:4066) qPCR引物对 (全名:LYL1 basic helix-loop-helix family member;别名:bHLHa18) Preci? human(人) ID4 (基因ID:3400) qPCR引物对 (全名:inhibitor of DNA binding 4;别名:IDB4,bHLHb27)(tnt9031a) Preci? human(人) ID3 (基因ID:3399) qPCR引物对 (全名:inhibitor of DNA binding 3;别名:HEIR-1,bHLHb25)(tnt2556a) Preci? human(人) ID2 (基因ID:3398) qPCR引物对 (全名:inhibitor of DNA binding 2;别名:GIG8,ID2A,ID2H,bHLHb26)(tnt2766b) Preci? human(人) ID1 (基因ID:3397) qPCR引物对 (全名:inhibitor of DNA binding 1;别名:ID,bHLHb24)(tnt2555b) Preci? human(人) HEYL (基因ID:26508) qPCR引物对 (全名:hes related family bHLH transcription factor with YRPW motif like;别名:HEY3,HRT3,HESR3,bHLHb33)(tnt3823b) Preci? human(人) HEY2 (基因ID:23493) qPCR引物对 (全名:hes related family bHLH transcription factor with YRPW motif 2;别名:GRL,CHF1,HRT2,HERP1,HESR2,bHLHb32,GRIDLOCK)(tnt2244a) Preci? human(人) HEY1 (基因ID:23462) qPCR引物对 (全名:hes related family bHLH transcription factor with YRPW motif 1;别名:CHF2,OAF1,HERP2,HESR1,HRT-1,NERP2,hHRT1,BHLHb31)(tnt4922c) Preci? human(人) HES7 (基因ID:84667) qPCR引物对 (全名:hes family bHLH transcription factor 7;别名:SCDO4,hHes7,bHLHb37) Preci? human(人) HES6 (基因ID:55502) qPCR引物对 (全名:hes family bHLH transcription factor 6;别名:HES-6,bHLHb41,bHLHc23,C-HAIRY1) Preci? human(人) HES5 (基因ID:388585) qPCR引物对 (全名:hes family bHLH transcription factor 5;别名:bHLHb38)(tnt3822c) Preci? human(人) HES4 (基因ID:57801) qPCR引物对 (全名:hes family bHLH transcription factor 4;别名:bHLHb42) Preci? human(人) HES3 (基因ID:390992) qPCR引物对 (全名:hes family bHLH transcription factor 3;别名:bHLHb43) Preci? human(人) HES2 (基因ID:54626) qPCR引物对 (全名:hes family bHLH transcription factor 2;别名:bHLHb40) Preci? human(人) HES1 (基因ID:3280) qPCR引物对 (全名:hes family bHLH transcription factor 1;别名:HHL,HRY,HES-1,bHLHb39)(tnt1511b) Preci? human(人) HELT (基因ID:391723) qPCR引物对 (全名:helt bHLH transcription factor;别名:Mgn,HESL,HCM1228,bHLHb44) Preci? human(人) HAND2 (基因ID:9464) qPCR引物对 (全名:heart and neural crest derivatives expressed 2;别名:Hed,dHand,DHAND2,Thing2,bHLHa26)(tnt6629b) Preci? human(人) HAND1 (基因ID:9421) qPCR引物对 (全名:heart and neural crest derivatives expressed 1;别名:Hxt,eHand,Thing1,bHLHa27) Preci? human(人) FIGLA (基因ID:344018) qPCR引物对 (全名:folliculogenesis specific bHLH transcription factor;别名:POF6,BHLHC8,FIGALPHA) Preci? human(人) FERD3L (基因ID:222894) qPCR引物对 (全名:Fer3 like bHLH transcription factor;别名:PTFB,NATO3,NTWIST,N-TWIST,bHLHa31) Preci? human(人) BHLHE41 (基因ID:79365) qPCR引物对 (全名:basic helix-loop-helix family member e41;别名:DEC2,FNSS1,hDEC2,BHLHB3,SHARP1)(tnt2235a) Preci? human(人) BHLHE40 (基因ID:8553) qPCR引物对 (全名:basic helix-loop-helix family member e40;别名:DEC1,HLHB2,BHLHB2,Clast5,SHARP2,STRA13,Stra14,SHARP-2)(tnt9565a) Preci? human(人) BHLHE23 (基因ID:128408) qPCR引物对 (全名:basic helix-loop-helix family member e23;别名:BETA4,BHLHB4,Beta3b,bA305P22.3) Preci? human(人) BHLHE22 (基因ID:27319) qPCR引物对 (全名:basic helix-loop-helix family member e22;别名:Beta3,BHLHB5,Beta3a,CAGL85,TNRC20) Preci? human(人) BHLHA15 (基因ID:168620) qPCR引物对 (全名:basic helix-loop-helix family member a15;别名:MIST1,BHLHB8) Preci? human(人) BHLHA9 (基因ID:727857) qPCR引物对 (全名:basic helix-loop-helix family member a9;别名:CCSPD,BHLHF42) Preci? human(人) ATOH8 (基因ID:84913) qPCR引物对 (全名:atonal bHLH transcription factor 8;别名:HATH6,bHLHa21) Preci? human(人) ATOH7 (基因ID:220202) qPCR引物对 (全名:atonal bHLH transcription factor 7;别名:Math5,NCRNA,RNANC,PHPVAR,bHLHa13) Preci? human(人) ATOH1 (基因ID:474) qPCR引物对 (全名:atonal bHLH transcription factor 1;别名:ATH1,HATH1,DFNA89,MATH-1,bHLHa14) Preci? human(人) ASCL5 (基因ID:647219) qPCR引物对 (全名:achaete-scute family bHLH transcription factor 5;别名:ASH-5,AmeloD,bHLHa47) Preci? human(人) ASCL4 (基因ID:121549) qPCR引物对 (全名:achaete-scute family bHLH transcription factor 4;别名:ASH-4,HASH4,bHLHa44) Preci? human(人) ASCL3 (基因ID:56676) qPCR引物对 (全名:achaete-scute family bHLH transcription factor 3;别名:SGN1,HASH3,bHLHa42) Preci? human(人) ASCL2 (基因ID:430) qPCR引物对 (全名:achaete-scute family bHLH transcription factor 2;别名:ASH2,HASH2,MASH2,bHLHa45)(tnt8735a) Preci? human(人) ASCL1 (基因ID:429) qPCR引物对 (全名:achaete-scute family bHLH transcription factor 1;别名:ASH1,HASH1,MASH1,bHLHa46)
“碱性螺旋-环-螺旋蛋白”(Basic helix-loop-helix proteins,简称bHLH蛋白)基因群是一类在生物体中广泛分布的转录因子家族,它们通过特定的DNA结合模式参与多种生物学过程。以下是关于bHLH蛋白基因群的详细信息和归纳:
结构和分类:
bHLH蛋白是一类含有“basic helix-loop-helix”(bHLH)结构域的转录因子。这一结构域约含60个氨基酸,分为碱性区域(basic region)和α螺旋-环-α螺旋(helix-loop-helix)结构。
碱性区域由15~20个氨基酸组成,能与DNA结合,特别是识别E-box(5´-CANNTG-3´)和G-box(5´-CACGTG-3´)序列。
α螺旋-环-α螺旋结构依赖疏水氨基酸的相互作用,促进蛋白形成同型或异型二聚体,因此bHLH蛋白常以二聚体的形式发挥作用。
根据bHLH与DNA结合模式的不同,可以分为能与E-box增强子结合的bHLH、能与N-box抑制子序列结合的bHLH和不能与DNA结合的bHLH等类别。
生物学功能:
bHLH蛋白在动植物中普遍存在,是植物中最大的转录因子家族之一,具有重要的生物学功能。
在植物中,它们参与调控花青素生物合成、表皮毛状体形成、气孔发育、种子萌发、果实成熟等过程。
在动物中,bHLH蛋白在胚胎发育、肌肉生成、神经发生、免疫应答等多个生物学过程中发挥重要作用。
基因群成员:
bHLH蛋白基因群包含多个成员,它们在结构和功能上可能有所不同,但都具有bHLH结构域这一共同特征。
例如,在哺乳动物中,E12和E47是两种典型的bHLH蛋白,它们在多种组织和器官中表达,并参与调控多种生物学过程。
与疾病的关系:
bHLH蛋白的异常表达或突变可能与某些疾病的发生有关。例如,某些bHLH蛋白的异常表达可能与癌症、神经退行性疾病等的发生和发展有关。
数字和信息:
bHLH结构域约含60个氨基酸,其中碱性区域由15~20个氨基酸组成。
81%的bHLH蛋白可识别G-box(5´-CACGTG-3´)序列。
在动物中,根据bHLH的碱性DNA结合模式不同,可将bHLH蛋白分为A、B、C、D、E和F六个组。
综上所述,“碱性螺旋-环-螺旋蛋白”基因群是一类重要的转录因子家族,通过特定的DNA结合模式参与多种生物学过程,并在动植物中发挥重要作用。它们的异常表达或突变可能与某些疾病的发生有关。