产品参数
Preci? human(人) KCNH8 (基因ID:131096) qPCR引物对 (全名:potassium voltage-gated channel subfamily H member 8;别名:ELK,ELK1,elk3,Kv12.1) Preci? human(人) KCNH7 (基因ID:90134) qPCR引物对 (全名:potassium voltage-gated channel subfamily H member 7;别名:ERG3,HERG3,Kv11.3) Preci? human(人) KCNH6 (基因ID:81033) qPCR引物对 (全名:potassium voltage-gated channel subfamily H member 6;别名:ERG2,ERG-2,HERG2,Kv11.2,hERG-2) Preci? human(人) KCNH5 (基因ID:27133) qPCR引物对 (全名:potassium voltage-gated channel subfamily H member 5;别名:EAG2,hEAG2,DEE112,H-EAG2,Kv10.2) Preci? human(人) KCNH4 (基因ID:23415) qPCR引物对 (全名:potassium voltage-gated channel subfamily H member 4;别名:BEC2,ELK1,Kv12.3) Preci? human(人) KCNH3 (基因ID:23416) qPCR引物对 (全名:potassium voltage-gated channel subfamily H member 3;别名:BEC1,ELK2,Kv12.2) Preci? human(人) KCNH2 (基因ID:3757) qPCR引物对 (全名:potassium voltage-gated channel subfamily H member 2;别名:ERG1,HERG,LQT2,SQT1,ERG-1,H-ERG,HERG1,Kv11.1) Preci? human(人) KCNH1 (基因ID:3756) qPCR引物对 (全名:potassium voltage-gated channel subfamily H member 1;别名:EAG,EAG1,ZLS1,hEAG,TMBTS,h-eag,hEAG1,Kv10.1,K(V)10.1) Preci? human(人) KCNA6 (基因ID:3742) qPCR引物对 (全名:potassium voltage-gated channel subfamily A member 6;别名:HBK2,KV1.6,PPP1R96) Preci? human(人) KCNV2 (基因ID:169522) qPCR引物对 (全名:potassium voltage-gated channel modifier subfamily V member 2;别名:Kv8.2,RCD3B,KV11.1) Preci? human(人) KCNV1 (基因ID:27012) qPCR引物对 (全名:potassium voltage-gated channel modifier subfamily V member 1;别名:HNKA,KCNB3,KV2.3,KV8.1) Preci? human(人) KCNS3 (基因ID:3790) qPCR引物对 (全名:potassium voltage-gated channel modifier subfamily S member 3;别名:KV9.3) Preci? human(人) KCNS2 (基因ID:3788) qPCR引物对 (全名:potassium voltage-gated channel modifier subfamily S member 2;别名:KV9.2) Preci? human(人) KCNS1 (基因ID:3787) qPCR引物对 (全名:potassium voltage-gated channel modifier subfamily S member 1;别名:Kv9.1) Preci? human(人) KCNQ5 (基因ID:56479) qPCR引物对 (全名:potassium voltage-gated channel subfamily Q member 5;别名:Kv7.5,MRD46) Preci? human(人) KCNQ4 (基因ID:9132) qPCR引物对 (全名:potassium voltage-gated channel subfamily Q member 4;别名:DFNA2,KV7.4,DFNA2A) Preci? human(人) KCNQ3 (基因ID:3786) qPCR引物对 (全名:potassium voltage-gated channel subfamily Q member 3;别名:EBN2,BFNC2,KV7.3) Preci? human(人) KCNQ2 (基因ID:3785) qPCR引物对 (全名:potassium voltage-gated channel subfamily Q member 2;别名:EBN,BFNC,DEE7,EBN1,ENB1,HNSPC,KV7.2,KCNA11) Preci? human(人) KCNQ1 (基因ID:3784) qPCR引物对 (全名:potassium voltage-gated channel subfamily Q member 1;别名:LQT,RWS,WRS,LQT1,SQT2,ATFB1,ATFB3,JLNS1,KCNA8,KCNA9,Kv1.9,Kv7.1,KVLQT1) Preci? human(人) KCNG4 (基因ID:93107) qPCR引物对 (全名:potassium voltage-gated channel modifier subfamily G member 4;别名:KV6.3,KV6.4) Preci? human(人) KCNG3 (基因ID:170850) qPCR引物对 (全名:potassium voltage-gated channel modifier subfamily G member 3;别名:KV6.3,KV10.1) Preci? human(人) KCNG2 (基因ID:26251) qPCR引物对 (全名:potassium voltage-gated channel modifier subfamily G member 2;别名:KCNF2,KV6.2) Preci? human(人) KCNG1 (基因ID:3755) qPCR引物对 (全名:potassium voltage-gated channel modifier subfamily G member 1;别名:K13,kH2,KCNG,KV6.1) Preci? human(人) KCNF1 (基因ID:3754) qPCR引物对 (全名:potassium voltage-gated channel modifier subfamily F member 1;别名:IK8,kH1,KCNF,KV5.1) Preci? human(人) KCND3 (基因ID:3752) qPCR引物对 (全名:potassium voltage-gated channel subfamily D member 3;别名:KV4.3,SCA19,SCA22,BRGDA9,KCND3L,KCND3S,KSHIVB) Preci? human(人) KCND2 (基因ID:3751) qPCR引物对 (全名:potassium voltage-gated channel subfamily D member 2;别名:RK5,KV4.2) Preci? human(人) KCND1 (基因ID:3750) qPCR引物对 (全名:potassium voltage-gated channel subfamily D member 1;别名:KV4.1) Preci? human(人) KCNC4 (基因ID:3749) qPCR引物对 (全名:potassium voltage-gated channel subfamily C member 4;别名:KV3.4,C1orf30,KSHIIIC,HKSHIIIC) Preci? human(人) KCNC3 (基因ID:3748) qPCR引物对 (全名:potassium voltage-gated channel subfamily C member 3;别名:KV3.3,SCA13,KSHIIID) Preci? human(人) KCNC2 (基因ID:3747) qPCR引物对 (全名:potassium voltage-gated channel subfamily C member 2;别名:KV3.2,DEE103) Preci? human(人) KCNC1 (基因ID:3746) qPCR引物对 (全名:potassium voltage-gated channel subfamily C member 1;别名:KV4,EPM7,NGK2,KV3.1) Preci? human(人) KCNB2 (基因ID:9312) qPCR引物对 (全名:potassium voltage-gated channel subfamily B member 2;别名:KV2.2) Preci? human(人) KCNB1 (基因ID:3745) qPCR引物对 (全名:potassium voltage-gated channel subfamily B member 1;别名:DRK1,DEE26,Kv2.1) Preci? human(人) KCNA10 (基因ID:3744) qPCR引物对 (全名:potassium voltage-gated channel subfamily A member 10;别名:Kcn1,Kv1.8) Preci? human(人) KCNA7 (基因ID:3743) qPCR引物对 (全名:potassium voltage-gated channel subfamily A member 7;别名:HAK6,KV1.7) Preci? human(人) KCNA5 (基因ID:3741) qPCR引物对 (全名:potassium voltage-gated channel subfamily A member 5;别名:HK2,HCK1,PCN1,ATFB7,HPCN1,KV1.5) Preci? human(人) KCNA4 (基因ID:3739) qPCR引物对 (全名:potassium voltage-gated channel subfamily A member 4;别名:HK1,HBK4,PCN2,HPCN2,HUKII,KCNA8,KV1.4,KCNA4L,MCIDDS) Preci? human(人) KCNA3 (基因ID:3738) qPCR引物对 (全名:potassium voltage-gated channel subfamily A member 3;别名:MK3,HGK5,HLK3,PCN3,HPCN3,KV1.3,HUKIII)(tnt8579a) Preci? human(人) KCNA2 (基因ID:3737) qPCR引物对 (全名:potassium voltage-gated channel subfamily A member 2;别名:HK4,MK2,HBK5,NGK1,RBK2,DEE32,HUKIV,KV1.2,EIEE32) Preci? human(人) KCNA1 (基因ID:3736) qPCR引物对 (全名:potassium voltage-gated channel subfamily A member 1;别名:EA1,MK1,AEMK,HBK1,HUK1,MBK1,RBK1,KV1.1)
“钾电压门控通道”(Potassium Voltage-Gated Channels)基因群是一个广泛而复杂的家族,这些通道在神经和肌肉细胞的电活动中起着至关重要的作用。以下是关于钾电压门控通道基因群的清晰概述:
基因家族成员:
钾电压门控通道由多个基因编码,这些基因编码的蛋白质具有不同的亚型和功能特性。例如,KCNA3(也称为KV1.3)是这一家族中的一个成员,编码电压门控钾通道,它在T细胞增殖和激活中起重要作用。
其他成员还包括KCNS3(KV9.3)、KCNG1等,这些基因编码的蛋白质在电压门控钾通道的不同亚家族中发挥作用。
染色体位置和基因组坐标:
钾电压门控通道基因在染色体上的位置各不相同。例如,KCNA3位于1号染色体的1p13.3区域,而KCNS3则位于2号染色体的2p24.2区域。
这些基因的基因组坐标可以根据不同的基因组组装版本(如GRCh38)进行精确定位。
功能特性:
钾电压门控通道在调节神经递质释放、心率、胰岛素分泌、神经元兴奋性、上皮电解质转运、平滑肌收缩和细胞体积等方面发挥重要作用。
这些通道通过开放和关闭来响应膜电位的变化,从而控制钾离子的跨膜流动,进而影响细胞的电活动。
转录本和蛋白质结构:
钾电压门控通道基因通常具有多个转录本(splice variants),这些转录本通过不同的剪接方式产生具有不同功能的蛋白质。
这些蛋白质通常包含六个跨膜结构域,其中第四部分具有振动型重复序列。这种结构使得它们能够形成高度选择性的离子通道。
与疾病的关系:
钾电压门控通道的功能异常与多种疾病有关,包括心律失常、癫痫、神经退行性疾病等。因此,对这些通道的研究有助于深入了解这些疾病的发病机制,并为开发新的治疗方法提供线索。
研究进展:
近年来,随着基因编辑和分子生物学技术的发展,对钾电压门控通道基因群的研究取得了显著进展。这些研究不仅揭示了这些通道在细胞电活动中的重要作用,还为我们理解相关疾病的发病机制提供了新的视角。
综上所述,“钾电压门控通道”基因群是一个复杂而重要的家族,在神经和肌肉细胞的电活动中发挥着至关重要的作用。对这些通道的研究不仅有助于我们深入理解细胞电活动的机制,还为开发新的治疗方法提供了重要的线索。