产品参数
Preci? human(人) SLC27A6 (基因ID:28965) qPCR引物对 (全名:solute carrier family 27 member 6;别名:FATP6,ACSVL2,FACVL2,VLCS-H1)(tnt8038b) Preci? human(人) SLC27A5 (基因ID:10998) qPCR引物对 (全名:solute carrier family 27 member 5;别名:BAL,ACSB,BACS,FATP5,ACSVL6,FACVL3,FATP-5,VLACSR,VLCSH2,VLCS-H2)(tnt8037b) Preci? human(人) SLC27A4 (基因ID:10999) qPCR引物对 (全名:solute carrier family 27 member 4;别名:IPS,FATP4,ACSVL4)(tnt8036b) Preci? human(人) SLC27A3 (基因ID:11000) qPCR引物对 (全名:solute carrier family 27 member 3;别名:FATP3,ACSVL3,VLCS-3)(tnt8035a) Preci? human(人) SLC27A2 (基因ID:11001) qPCR引物对 (全名:solute carrier family 27 member 2;别名:VLCS,FATP2,VLACS,ACSVL1,FACVL1,hFACVL1,HsT17226)(tnt8034b) Preci? human(人) SLC27A1 (基因ID:376497) qPCR引物对 (全名:solute carrier family 27 member 1;别名:FATP,FATP1,ACSVL5,FATP-1)(tnt8033b) Preci? human(人) ACSS3 (基因ID:79611) qPCR引物对 (全名:acyl-CoA synthetase short chain family member 3;别名:) Preci? human(人) ACSS2 (基因ID:55902) qPCR引物对 (全名:acyl-CoA synthetase short chain family member 2;别名:ACS,ACSA,ACAS2,ACECS,AceCS1,dJ1161H23.1)(tnt9455a) Preci? human(人) ACSS1 (基因ID:84532) qPCR引物对 (全名:acyl-CoA synthetase short chain family member 1;别名:ACAS2L,ACECS1,AceCS2L) Preci? human(人) ACSM6 (基因ID:142827) qPCR引物对 (全名:acyl-CoA synthetase medium chain family member 6;别名:C10orf129,bA310E22.3) Preci? human(人) ACSM5 (基因ID:54988) qPCR引物对 (全名:acyl-CoA synthetase medium chain family member 5;别名:)(tnt7985a) Preci? human(人) ACSM4 (基因ID:341392) qPCR引物对 (全名:acyl-CoA synthetase medium chain family member 4;别名:)(tnt7984b) Preci? human(人) ACSM3 (基因ID:6296) qPCR引物对 (全名:acyl-CoA synthetase medium chain family member 3;别名:SA,SAH)(tnt7983a) Preci? human(人) ACSM2B (基因ID:348158) qPCR引物对 (全名:acyl-CoA synthetase medium chain family member 2B;别名:HXMA,ACSM2,HYST1046) Preci? human(人) ACSM2A (基因ID:123876) qPCR引物对 (全名:acyl-CoA synthetase medium chain family member 2A;别名:ACSM2,A-923A4.1) Preci? human(人) ACSM1 (基因ID:116285) qPCR引物对 (全名:acyl-CoA synthetase medium chain family member 1;别名:BUCS1,MACS1) Preci? human(人) ACSL6 (基因ID:23305) qPCR引物对 (全名:acyl-CoA synthetase long chain family member 6;别名:ACS2,FACL6,LACS2,LACS5,LACS 6)(tnt7982a) Preci? human(人) ACSL5 (基因ID:51703) qPCR引物对 (全名:acyl-CoA synthetase long chain family member 5;别名:ACS2,ACS5,FACL5,DIAR13)(tnt7981c) Preci? human(人) ACSL4 (基因ID:2182) qPCR引物对 (全名:acyl-CoA synthetase long chain family member 4;别名:ACS4,FACL4,LACS4,MRX63,MRX68,XLID63)(tnt7980b) Preci? human(人) ACSL3 (基因ID:2181) qPCR引物对 (全名:acyl-CoA synthetase long chain family member 3;别名:ACS3,FACL3,LACS3,LACS 3,PRO2194)(tnt7979a) Preci? human(人) ACSL1 (基因ID:2180) qPCR引物对 (全名:acyl-CoA synthetase long chain family member 1;别名:ACS1,LACS,FACL1,FACL2,LACS1,LACS2)(tnt7978a) Preci? human(人) ACSF3 (基因ID:197322) qPCR引物对 (全名:acyl-CoA synthetase family member 3;别名:) Preci? human(人) ACSF2 (基因ID:80221) qPCR引物对 (全名:acyl-CoA synthetase family member 2;别名:ACSMW,AVYV493) Preci? human(人) ACSBG2 (基因ID:81616) qPCR引物对 (全名:acyl-CoA synthetase bubblegum family member 2;别名:BGR,BRGL,PRTDNY3,PRTD-NY3)(tnt7977b) Preci? human(人) ACSBG1 (基因ID:23205) qPCR引物对 (全名:acyl-CoA synthetase bubblegum family member 1;别名:BG,BG1,BGM,LPD,GR-LACS)(tnt7976a) Preci? human(人) AASDH (基因ID:132949) qPCR引物对 (全名:aminoadipate-semialdehyde dehydrogenase;别名:LYS2,ACSF4,NRPS998,NRPS1098)(tnt9028a) Preci? human(人) AACS (基因ID:65985) qPCR引物对 (全名:acetoacetyl-CoA synthetase;别名:ACSF1,SUR-5)
酰基辅酶A合成酶家族(Acyl-CoA Synthetase Family)基因群是生物体内一类至关重要的酶类,它们在细胞内的脂肪代谢过程中扮演着核心角色。以下是关于这个基因群的详细解释:
家族成员:
ACSL1、ACSL3、ACSL4、ACSL5及ACSL6是酰基辅酶A合成酶长链家族(ACSLs)的五个主要成员。这些酶在细胞内激活脂肪酸,进而参与脂代谢、脂肪酸代谢等生物过程。
ACSF2和ACSF3是另外两个家族成员,它们同样在脂质代谢和能量产生过程中发挥重要作用。
结构与功能:
ACSLs家族的成员通常具有镁离子结合、长链脂肪酸辅酶A连接酶和连接酶的活性。这些酶通过催化脂肪酸和辅酶A之间形成硫酯键,将脂肪酸转化为脂肪酰基辅酶A,从而参与后续的代谢过程。
例如,ACSL3可激活碳链长度为16~20的不饱和脂肪酸以及全顺式-5,8,11,14-二十碳四烯酸,并生成蛋黄素以及脂滴。
分布与表达:
ACSLs家族的成员通常分布于细胞膜或融入膜中。例如,人类ACSL3基因位于2q36.1,而ACSF3基因则位于16q24.3。
这些基因的表达模式可能因细胞类型、组织类型或发育阶段的不同而有所差异。例如,ACSL3在大脑中的表达水平较高。
与人类疾病关联:
ACSLs家族的成员与多种人类疾病有关。例如,ACSL4基因的突变与智力低下等神经系统疾病有关。ACSF3基因的突变则可能导致丙二酸和甲基丙二酸尿症。
研究意义:
酰基辅酶A合成酶家族基因群的研究有助于深入了解细胞内的脂质代谢和能量产生过程,为相关疾病的预防和治疗提供新的思路和方法。例如,通过调节ACSF2的活性,可能有助于改善代谢性疾病和能量平衡失调的代谢状态。
总之,酰基辅酶A合成酶家族基因群在生物体内发挥着至关重要的作用,是生命科学领域的重要研究对象之一。