BioTNT PCR Array ，信号通路检测，小工具，大用途!

小编为您推荐三款筛选信号通路的PCR Array（pathway finder），如果您只专注于其中的一两条通路，也可以自由组合哦！

推荐1： Human Signal Transduction PathwayFinderPCR Array（人信号转导pathwayfinder PCR Array）

TGFß Pathway: ATF4, CDKN1B (p27KIP1), EMP1, GADD45B,HERPUD1, IFRD1, MYC, TNFSF10 (TRAIL).

WNT Pathway: AXIN2, CCND1, CCND2, DAB2, FOSL1 (FRA-1), MMP7(Matrilysin), MYC, PPARD, WISP1.

NFκB Pathway: BCL2A1 (Bfl-1/A1), BCL2L1 (BCL-X),BIRC3 (c-IAP1), CCL5 (RANTES), CSF1 (MCSF), ICAM1, IFNG, STAT1, TNF.

JAK/STAT Pathway:         

JAK1, 2 / STAT1: IRF1. 

STAT3: BCL2L1 (BCL-X), CCND1, CEBPD, LRG1,MCL1, SOCS3. 

STAT5: BCL2L1 (BCL-X), CCND1, SOCS3.            

JAK1, 3 / STAT6: FCER2, GATA3.          

p53 Pathway: BAX, BBC3, BTG2, CDKN1A (p21CIP1/WAF1), EGFR, FAS(TNFRSF6), GADD45A, PCNA, RB1.

Notch Pathway: HES1, HES5, HEY1, HEY2, HEYL, ID1,JAG1, LFNG, NOTCH1. 

Hedgehog Pathway: BCL2, BMP2, BMP4, PTCH1, WNT1, WNT2B,WNT3A, WNT5A, WNT6. 

PPAR Pathway: ACSL3, ACSL4, ACSL5, CPT2, FABP1, OLR1,SLC27A4, SORBS1.   

Oxidative Stress: FTH1, GCLC, GCLM, GSR, HMOX1, NQO1,SQSTM1, TXN, TXNRD1.  

Hypoxia: ADM, ARNT, CA9, EPO, HMOX1, LDHA, SERPINE1(PAI-1), SLC2A1, VEGFA.

推荐2：Human Stress & Toxicity PathwayFinderPCR Array（人应激和毒性pathwayfinder PCR Array）

介绍：这是一款通用的人应激和毒性pathwayfinder：

Oxidative Stress（氧化应激）: FTH1, GCLC, GCLM, GSR, GSTP1, HMOX1,NQO1, PRDX1, SQSTM1, TXN, TXNRD1.

Hypoxia: ADM, ARNT, BNIP3L, CA9, EPO, HMOX1, LDHA, MMP9(Gelatinase B), SERPINE1 (PAI-1), SLC2A1, VEGFA.

Osmotic Stress（渗透性应激）: AKR1B1, AQP1, AQP2, AQP4, CFTR, EDN1,HSPA4L, NFAT5, SLC5A3.                                               

Cell Death（细胞死亡）: 

Apoptosis: CASP1 (ICE), FAS, MCL1, TNFRSF10A,TNFRSF10B (DR5), TNFRSF1A.

Autophagy: ATG5, ATG7, ATG12, BECN1, FAS, ULK1.

Necrosis: FAS (TNFRSF6), GRB2, PARP1 (ADPRT1), PVR, RIPK1,TNFRSF10A, TNFRSF1A, TXNL4B.

Inflammatory Response(炎症应答): CCL2 (MCP-1), CD40LG (TNFSF5), CRP,IFNG, IL1A, IL1B, IL6, IL8, TLR4, TNF.

DNA Damage Signaling (DNA损伤): 

Cell Cycle Checkpoint/Arrest: CDKN1A (p21CIP1/WAF1), CHEK1, CHEK2(RAD53), DDIT3 (GADD153/CHOP), HUS1, MRE11A, NBN (NBS1), RAD17, RAD9A.

Other Responses: ATM, ATR, DDB2, GADD45A, GADD45G,RAD51, TP53, XPC.

Heat Shock Proteins/Unfolded Protein Response（热休克蛋白等）: ATF4, ATF6, ATF6B, BBC3, BID, CALR,DDIT3, DNAJC3, HSP90AA1, HSP90B1 (TRA1), HSPA4 (HSP70), HSPA5 (GRP78).

推荐3：Human Cancer PathwayFinder PCR Array（人癌症Pathway Finder PCR Array）

介绍：这是一款通用的癌症pathwayfinder，包括细胞循环/DNA 损伤修复；

Cell Cycle Control & DNA DamageRepair（细胞循环/DNA 损伤修复）:

ATM, BRCA1, CCNE1 (cyclin E1), CDC25A,CDK2, CDK4, CDKN1A (p21Waf1), CDKN2A (p16Ink4), CHEK2 (chk2 / Rad53), E2F1,MDM2, RB1, S100A4, TP53 (p53).

Apoptosis and Cell Senescence (细胞凋亡和细胞衰老):

APAF1, BAD, BAX, BCL2, BCL2L1 (bcl-X),CASP8, CFLAR (CASPER), FAS, GZMA, HTATIP2, TERT (telomerase), TNFRSF1A (TNF-areceptor), TNFRSF10B (DR5), TNFRSF25 (DR3).

Signal Transduction Molecules andTranscription Factors（信号转导分子和转录因子）:

AKT1, ERBB2, ETS2, FOS, JUN, MAP2K1(MEK), MYC, NFKB1 (NFκB), NFKBIA (IκBα), PIK3R1 (PI3K p85α), RAF1, SNCG.

Adhesion（粘附分子）:

ITGA1 (integrin α1), ITGA2 (integrinα2), ITGA3 (integrin α3), ITGA4 (integrin α4), ITGAV (integrin αV), ITGB1(integrin β1), ITGB3 (integrin β3), ITGB5 (integrin β5), MCAM, MTSS1, PNN, SYK,EPDR1.

Angiogenesis（血管生成）:

ANGPT1 (angiopoietin-1), ANGPT2(angiopoietin-2), COL18A1 (endostatin), FGFR2, IFNA1 (IFNα), IFNB1 (IFNβ),IGF1, IL8, PDGFA, PDGFB, TEK (tie-2), TGFB1, TGFBR1 (ALK-5), THBS1 (thrombospondin-1),TNF, VEGFA.

Invasion and Metastasis（细胞侵入和瘤转移）:

MET, MMP1 (collagenase-1), MMP2(gelatinase A), MMP9 (gelatinase B), MTA1, MTA2, NME1, NME4, PLAU, PLAUR,S100A4, SERPINB5 (maspin), SERPINE1 (PAI1), TIMP1, TIMP3, TWIST1.

也许，您要说，我不想检测那么多，我只想检测一两条通路，怎么办？

上面的PCR Array，每一条通路，您都可以自由组合，作为您DIY的PCR Array，您看人性化吧！

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